4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Base Information

Chemical Name:4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide
CAS No.:355133-88-9
Molecular Formula:C₂₃H₃₄N₄O₄S₂
Molecular Weight:494.679
Hs Code.:

Synonyms:4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

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Chemical Property of 4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

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Technology Process of 4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

There total 5 articles about 4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 594-44-5
Ethanesulfonyl chloride

: 355133-87-8
4-(7-cyclohexyl-5-nitro-3,4-dihydro-1-naphthalenyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

: 355133-88-9
4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Guidance literature:: palladium-carbon; In 1,4-dioxane; pyridine; ethanol;

Reference yield:

: 64959-04-2
7-cyclohexyl-3,4-dihydro-1(2H)-naphthalenone

: 355133-88-9
4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1.5 g / H₂SO₄; NaNO₃ / 2 h / 0 °C

2.1: EtMgBr / CH₂Cl₂; diethyl ether / 0.5 h

2.2: CH₂Cl₂; diethyl ether / 20 °C

3.1: TFA / 2 h / Heating

4.1: H₂ / Pd/C / ethyl acetate / 16 h / 760 Torr

5.1: pyridine / CH₂Cl₂ / 20 °C

With pyridine; sodium nitrate; sulfuric acid; ethylmagnesium bromide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm030551a

Reference yield:

: 355133-86-7
7-cyclohexyl-5-nitro-3,4-dihydro-1(2H)-naphthalenone

: 355133-88-9
4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: EtMgBr / CH₂Cl₂; diethyl ether / 0.5 h

1.2: CH₂Cl₂; diethyl ether / 20 °C

2.1: TFA / 2 h / Heating

3.1: H₂ / Pd/C / ethyl acetate / 16 h / 760 Torr

4.1: pyridine / CH₂Cl₂ / 20 °C

With pyridine; ethylmagnesium bromide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm030551a