64959-04-2

Upstream product

• 54338-32-8 4-(4-cyclohexylphenyl)butanoic Acid 
• 110-83-8 cyclohexene 
• 854838-53-2 (4-cyclohexyl-phenethyl)-malonic acid diethyl ester 
• 690224-27-2 4-cyclohexyl-phenethyl alcohol 
• 188396-68-1 1-(2-bromoethyl)-4-cyclohexylbenzene 
• 35288-13-2 3-(4-cyclohexylbenzoyl)propionic acid 
• 827-52-1 1-phenyl-1-cyclohexane 
• 604-44-4 4-chloronaphthalen-1-ol 
• 110-82-7 cyclohexane 
• 90-15-3 α-naphthol 
• 96-37-7 methyl-cyclopentane 
• 56462-19-2 4-(4-cyclohexyl-phenyl)-butyryl chloride 

Downstream Products

• 355133-86-7 7-cyclohexyl-5-nitro-3,4-dihydro-1(2H)-naphthalenone 
• 22583-68-2 7-(1,1-dimethylethyl)-3,4-dihydro-1(2H)-naphthalenone 
• 41526-73-2 7-phenyl-3,4-dihydronaphthalen-1(2H)-one 
• 175394-02-2 methyl 7-cyclohexyl-1-tetralone-2-carboxylate 
• 35338-72-8 7-isopropyl-3,4-dihydro-2H-naphthalen-1-one 
• 19550-57-3 6,7-dimethyl-1-tetralone 
• 93151-09-8 6-cyclohexyltetralin 
• 355133-88-9 4-{7-cyclohexyl-5-[(ethylsulfonyl)amino]-1,2,3,4-tetrahydro-1-naphthalenyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide 
• 355133-87-8 4-(7-cyclohexyl-5-nitro-3,4-dihydro-1-naphthalenyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide 

Relevant academic research and scientific papers

Green synthesis method of medical intermediate benzocyclohexanone compound

The invention provides a green synthesis method of a benzocyclohexanone compound, and belongs to the technical field of organic synthesis. The method provided by the invention comprises the followingsteps: by taking 4-phenylbutyric acid as a raw material, firstly carrying out reflux reaction with oxalyl chloride in dichloromethane, carrying out vacuum evaporation to dryness to obtain a crude product of the 4-phenylbutyryl chloride compound, then dissolving the crude product in a solvent, adding a metal-doped modified molecular sieve catalyst to start reaction, and stirring the solution at different temperatures to carry out ring closing reaction, thereby obtaining the product; and after the reaction is finished, carrying out suction filtration, solvent washing, column chromatography purification and other operations to obtain the target product benzocyclohexanone compound. The synthesis method disclosed by the invention is environment-friendly in reaction and simple and convenient tooperate, the catalyst can be recycled, and the synthesis method is suitable for green synthesis of the benzocyclohexanone compound.

4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE

A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof. This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.

4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use

Compounds of formula I are useful in treating diseases prevented by or ameliorated with α1A agonists. Also disclosed are α1A agonist compositions and a method of activating α1 adrenoceptors in a mammal.

Hydrocarbon humps in the marine environment: Synthesis, toxicity, and aqueous solubility of monoaromatic compounds

A recent study has shown that some monoaromatic hydrocarbon constituents of the so-called unresolved complex mixtures (UCMs) or gas chromatographic humps, which are widespread in the marine environment, are toxic to the mussel Mytilus edulis. Here we describe the synthesis and toxicological assessment of 6-cyclohexyltetralin, 7-cyclohexyl-1-methyltetralin, and 7-cyclohexyl-1-n-propyltetralin, which contain structural features consistent with some monoaromatic UCM hydrocarbons. The compounds were all toxic to M. edulis when measured in the assay used previously to determine the toxicity of a monoaromatic UCM. The aqueous solubilities of the hydrocarbons in fresh and seawater at different temperatures were determined and found to range from about 10 to 110 μg/L (10-60 μg/L in seawater at 15°C). Further studies of the aromatic UCM composition of a wide range of oils and oil residues are required to determine whether such alkylated compounds as 7-cyclohexyl-1-methyltetralin and 7-cyclohexyl-1-n-propyltetralin or their analogues are widespread in oils. If these aromatic compounds prove to be important in UCMs, toxicity experiments should be conducted with other biological end points and monitoring studies of pollutant hydrocarbons should probably include measurement of aromatic UCM hydrocarbons.

Phosphonic acid compounds, their production and use

The present invention relates to a compound of the general formula (I): STR1 wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q1 is a group of the formula --X--P(O)(OR1)(OR2) wherein X is a bond or a divalent group; R1 and R2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula --CON(Q1)(Q2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.

Ionic Hydrogenation of 1-Naphthol Derivatives with Alkanes in the Presence of Aluminum Halides

Reactions of 1-naphthol, 4-methyl-1-naphthol, 3-phenyl-1-naphthol, and 4-chloro-1-naphthol with cyclohexane, as well as of 1-naphthol with methylcyclopentane, pentane, isobutane, and propane, in the presence of excess aluminum chloride or bromide yield α-tetralone derivatives as a result of regioselective ionic hydrogenation. Abstraction of the hydride ion from alkane is effected by the protonated complex of the keto form of the naphthol with aluminum halide.