(1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid

Base Information

Chemical Name:(1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid
CAS No.:1412974-73-2
Molecular Formula:C₂₄H₂₇FN₂O₅S
Molecular Weight:474.553
Hs Code.:

Synonyms:(1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid

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Chemical Property of (1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid

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Technology Process of (1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid

There total 28 articles about (1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (1aS,7bR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluoro-benzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1412974-73-2
(1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid

Guidance literature:: methyl (1aS,7bR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluoro-benzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate; With water; lithium hydroxide; In 1,4-dioxane; at 85 ℃;

With formic acid; In methanol;

With citric acid; In 1,4-dioxane; water;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1412974-73-2
(1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1R,2R)-trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane / nickel(I) iodide / isopropyl alcohol / 0.08 h / 40 °C / Sealed tube; Inert atmosphere

1.2: 70 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C

4.1: chlorosulfonic acid / 1,2-dichloro-ethane / 2 h / 20 °C

5.1: dichloromethane; pyridine / 20 °C

6.1: water; lithium hydroxide / 1,4-dioxane / 85 °C

With chlorosulfonic acid; water; sodium hexamethyldisilazane; potassium carbonate; (1R,2R)-trans-2-aminocyclohexanol hydrochloride; trifluoroacetic acid; lithium hydroxide; nickel(I) iodide; In 1,4-dioxane; pyridine; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 138108-72-2
tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate

: 1412974-73-2
(1aRS,7bSR)-5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluombenzenesulfonyl-amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-catboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / 1,4-dioxane; diethyl ether / 20 °C / Cooling with ice

1.2: 20 °C

2.1: (1R,2R)-trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane / nickel(I) iodide / isopropyl alcohol / 0.08 h / 40 °C / Sealed tube; Inert atmosphere

2.2: 70 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C

5.1: chlorosulfonic acid / 1,2-dichloro-ethane / 2 h / 20 °C

6.1: dichloromethane; pyridine / 20 °C

7.1: water; lithium hydroxide / 1,4-dioxane / 85 °C

With 1H-imidazole; chlorosulfonic acid; water; iodine; sodium hexamethyldisilazane; potassium carbonate; triphenylphosphine; (1R,2R)-trans-2-aminocyclohexanol hydrochloride; trifluoroacetic acid; lithium hydroxide; nickel(I) iodide; In 1,4-dioxane; pyridine; diethyl ether; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;