methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate

Base Information

• Chemical Name: methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate
• CAS No.: 1146208-19-6
• Molecular Formula: C₂₀H₂₀N₂O₄S
• Molecular Weight: 384.456
• Mol file: 1146208-19-6.mol

Synonyms:methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate

Chemical Property of methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate

There total 2 articles about methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) + 4-methoxycarbonyl aniline (619-45-4) → methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate (1146208-19-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.6b01191

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate (1146208-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 8 h / Reflux

2: triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

With sulfuric acid; triethylamine; In dichloromethane;

DOI:10.1021/acs.joc.6b01191

Reference yield: 77.0%

methyl 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoate (1146208-19-6) → 4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoic acid (34532-42-8)

Guidance literature:

With lithium hydroxide; In methanol; at 20 ℃; for 12h;

DOI:10.1021/acs.joc.6b01191

upstream raw materials:

5-(dimethylamino)naphth-1-ylsulfonyl chloride

4-methoxycarbonyl aniline

4-amino-benzoic acid

Downstream raw materials:

N-dansyl-4-aminobenzene carbohydrazide

4-(5-(dimethylamino)naphthalene-1-sulfonamido)benzoic acid