Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:221099-73-6
Molecular Formula:C₃₀H₃₀O₄
Molecular Weight:454.566
Hs Code.:

Synonyms:Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 6 articles about Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 25726-04-9
phenylglyoxylyl chloride

: 221099-71-4
exo-10,10-diphenyl-10-hydroxymethyl-7,7-dimethylbicyclo[2.2.1]heptane-2-ol

: 221099-73-6
Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 4h;
DOI:10.1021/jo9902188

Reference yield:

: 125637-45-8
(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic acid methylester

: 221099-73-6
Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / tetrahydrofuran / 0.5 h / 0 °C

2: 95 percent / LAH / tetrahydrofuran / 0.5 h / -78 °C

3: 99 percent / tetrahydrofuran / 4 h / 0 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; 1: Grignard reaction / 2: Reduction / 3: Esterification;
DOI:10.1021/jo9902188

Reference yield:

: 611-73-4
Benzoylformic acid

: 221099-73-6
Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / 65 °C

2: 99 percent / tetrahydrofuran / 4 h / 0 °C

With thionyl chloride; In tetrahydrofuran; 1: Chlorination / 2: Esterification;
DOI:10.1021/jo9902188