N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide

Base Information

Chemical Name:N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide
CAS No.:1445901-40-5
Molecular Formula:C₂₂H₂₆F₃N₃O₃S
Molecular Weight:469.528
Hs Code.:

Synonyms:N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide

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Chemical Property of N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide

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Technology Process of N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide

There total 4 articles about N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1445902-97-5
N-(4-(4-acetylpiperazin-1-yl)benzyl)-1-phenylmethanesulfonamide

: 1445901-40-5
N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide

Guidance literature:: N-(4-(4-acetylpiperazin-1-yl)benzyl)-1-phenylmethanesulfonamide; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 0.5h;

2,2,2-trifluoroethyl trifluoromethanesulphonate; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 16h;

Reference yield:

: 1939-99-7
benzenesulfonyl chloride

: 1445901-40-5
N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2.1: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0.5 h / 20 °C

3.2: 16 h / 20 °C

With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; ruphos; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; mineral oil;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 1445901-40-5
N-[4-(4-acetylpiperazin-1-yl)benzyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2.1: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0.5 h / 20 °C

3.2: 16 h / 20 °C

With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; ruphos; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; mineral oil;