(2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

Base Information

• Chemical Name: (2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one
• CAS No.: 170309-37-2
• Molecular Formula: C₂₁H₂₄N₂O₂
• Molecular Weight: 336.434
• Mol file: 170309-37-2.mol

Synonyms:(2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

Chemical Property of (2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

There total 4 articles about (2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

benzoic acid anhydride (93-97-0) + 2--N''-<(R)-α-methylbenzyl>acetamide (170309-34-9) → (2S,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one (170309-36-1) + (2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one (170309-37-2)

Guidance literature:

In toluene; for 7h; Heating;

DOI:10.1021/jo00125a029

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → (2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one (170309-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) oxalyl chloride / 1.) CH₂Cl₂, DMF, room temperature, 2 h, 2.) room temperature, overnight

2: 100 percent / H₂ / Pd/C / methanol / 35 °C / 7600 Torr

3: Et₃N / CH₂Cl₂ / 5 h / Heating

4: 8 percent / toluene / 7 h / Heating

With oxalyl dichloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; toluene;

DOI:10.1021/jo00125a029

Reference yield:

2--N''-<(R)-α-methylbenzyl>acetamide (170309-33-8) → (2R,1'R)-1-benzoyl-2-isopropyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one (170309-37-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / methanol / 35 °C / 7600 Torr

2: Et₃N / CH₂Cl₂ / 5 h / Heating

3: 8 percent / toluene / 7 h / Heating

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; toluene;

DOI:10.1021/jo00125a029

upstream raw materials:

benzoic acid anhydride

2--N''-<(R)-α-methylbenzyl>acetamide

(R)-1-phenyl-ethyl-amine

2-Amino-N-((R)-1-phenyl-ethyl)-acetamide

Downstream raw materials:

(2R,5R,1'R)-1-benzoyl-2-isopropyl-5-methyl-3-(α-methylbenzyl)-1,3-imidazolidin-4-one