1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Base Information

Chemical Name:1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one
CAS No.:1256783-00-2
Molecular Formula:C₁₉H₂₃F₃N₄O
Molecular Weight:380.413
Hs Code.:

Synonyms:1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

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Chemical Property of 1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Chemical Property:

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Technology Process of 1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

There total 7 articles about 1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-85-0
piperazine

: 1256783-06-8
1-(2-((2-chloroethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

: 1256783-00-2
1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Guidance literature:: sodium iodide; In acetonitrile; for 20h; Reflux;

Reference yield:

: 33252-63-0,79894-13-6
5-(trifluoromethyl)-2(1H)-pyridone

: 1256783-00-2
1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / Reflux

2.1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux

2.2: 50 °C / pH 8

3.1: potassium carbonate / butan-1-ol / 18 h / 130 °C

4.1: thionyl chloride; triethylamine / dichloromethane / 10 h / 20 °C

5.1: sodium iodide / acetonitrile / 20 h / Reflux

With hydrogenchloride; thionyl chloride; iron; sodium carbonate; potassium carbonate; triethylamine; sodium iodide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 1256782-96-3
1-(2-nitrobenzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

: 1256783-00-2
1-(2-((2-(piperazin-1-yl)ethyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux

1.2: 50 °C / pH 8

2.1: potassium carbonate / butan-1-ol / 18 h / 130 °C

3.1: thionyl chloride; triethylamine / dichloromethane / 10 h / 20 °C

4.1: sodium iodide / acetonitrile / 20 h / Reflux

With hydrogenchloride; thionyl chloride; iron; potassium carbonate; triethylamine; sodium iodide; In ethanol; dichloromethane; water; acetonitrile; butan-1-ol;