3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid

Base Information

Chemical Name:3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid
CAS No.:164336-14-5
Molecular Formula:C₂₃H₂₅N₃O₅
Molecular Weight:423.469
Hs Code.:

Synonyms:3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid

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Chemical Property of 3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid

Chemical Property:

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Technology Process of 3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid

There total 8 articles about 3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-88-4
methyl iodide

: 164336-13-4
(3-tert-butoxycarbonylamino-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetic acid

: 164336-14-5
3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid

Guidance literature:: With citric acid; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 149620-85-9
tert-butyl 2-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4] diazepin-1-yl)acetate

: 164336-14-5
3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane; trifluoroacetic acid

2: potassium tert-butylate / hexane

3: aluminum nickel / methanol; acetic acid

4: triethylamine / water; N,N-dimethyl-formamide

5: citric acid / tetrahydrofuran; ethyl acetate

With potassium tert-butylate; triethylamine; citric acid; aluminum nickel; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid;

Reference yield:

: 14439-71-5
2'-benzoyl-2-bromo-acetanilide

: 164336-14-5
3-(tert-butoxycarbonyl)methylamino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one-1-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: ammonia / methanol; water

2: caesium carbonate

3: dichloromethane; trifluoroacetic acid

4: potassium tert-butylate / hexane

5: aluminum nickel / methanol; acetic acid

6: triethylamine / water; N,N-dimethyl-formamide

7: citric acid / tetrahydrofuran; ethyl acetate

With potassium tert-butylate; ammonia; caesium carbonate; triethylamine; citric acid; aluminum nickel; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid;