(E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one

Base Information

• Chemical Name: (E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one
• CAS No.: 145626-24-0
• Molecular Formula: C₁₅H₁₁ClO₂
• Molecular Weight: 258.704
• Mol file: 145626-24-0.mol

Synonyms:(E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one

Chemical Property of (E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one

There total 6 articles about (E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.57%

2-chloro-benzaldehyde (89-98-5) + o-hydroxyacetophenone (118-93-4,104809-67-8) → (E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one (145626-24-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 0.0194444h; Microwave irradiation;

DOI:10.1016/j.molstruc.2020.127678

Reference yield: 80.0%

ethanol (64-17-5) + 2-chloro-benzaldehyde (89-98-5) + o-hydroxyacetophenone (118-93-4,104809-67-8) → (E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one (145626-24-0) + (2E,4E)-5-(2-Chloro-phenyl)-1-(2-hydroxy-phenyl)-penta-2,4-dien-1-one

Guidance literature:

With sodium hydroxide; at 20 ℃; for 5h;

Reference yield: 69.0%

2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) + salicylaldehyde (90-02-8) → (E)-1-(2-hydroxy-phenyl)-3-(2-chloro-phenyl)-prop-2-en-1-one (145626-24-0)

Guidance literature:

With 1,2,3,4-tetraphenylcyclopentadiene; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In 1,2-dichloro-ethane; at 120 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201203224

upstream raw materials:

2-chloro-benzaldehyde

o-hydroxyacetophenone

ethanol

2-chlorostyrene

Downstream raw materials:

2-(5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol

2,3-dihydro-2-(2,-chlorophenyl)-4H-1-benzopyran-4-one

C₁₈H₁₇ClO₃

C₂₁H₂₆ClNO₃