2-Vinyloxytetrahydropyran

Base Information

• Chemical Name: 2-Vinyloxytetrahydropyran
• CAS No.: 22408-41-9
• Molecular Formula: C7H12O2
• Molecular Weight: 128.171
• Hs Code.: 2932999099
• European Community (EC) Number: 678-342-0
• DSSTox Substance ID: DTXSID30468053
• Nikkaji Number: J2.259.362E
• Mol file: 22408-41-9.mol

Synonyms:2-Vinyloxytetrahydropyran;22408-41-9;2-ethenoxyoxane;2-(vinyloxy)tetrahydro-2h-pyran;Tetrahydro-2-vinyloxy-2H-pyran;SCHEMBL414222;DTXSID30468053;BYUNYALHUMSCSA-UHFFFAOYSA-N;XAA40841;2-Vinyloxytetrahydropyran, >/=97%;MFCD03093644;AKOS015903386;AS-43631;V0076

Chemical Property of 2-Vinyloxytetrahydropyran

Chemical Property:

• Vapor Pressure: 0.634mmHg at 25°C
• Refractive Index: 1.444
• Boiling Point: 193.9 °C at 760 mmHg
• Flash Point: 70.3 °C
• PSA: 18.46000
• Density: 0.95 g/cm³
• LogP: 1.67310
• Storage Temp.: Refrigerator
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.083729621
• Heavy Atom Count: 9
• Complexity: 90.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Vinyloxytetrahydropyran ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=COC1CCCCO1
• Uses: 2-Vinyloxytetrahydropyran is used in preparation of Alkylidene Molybdenum and Tungsten compounds and their use in metathesis catalysis reactions.Also, is used in preparation of nucleotide Phosphonate analogs as antiviral agents.

Technology Process of 2-Vinyloxytetrahydropyran

There total 1 articles about 2-Vinyloxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4) → Tetrahydropyranyl vinyl ether (22408-41-9)

Guidance literature:

With sodium hydroxide; tetrabutylammonium sulfate; In benzene; at 50 ℃; for 6h;

DOI:10.1021/jo00235a010

Reference yield: 94.0%

Tetrahydropyranyl vinyl ether (22408-41-9) + (E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one (288093-79-8) → (E)-2-Methyl-1-phenyl-4-(tetrahydro-pyran-2-yloxy)-penta-1,4-dien-3-one

Guidance literature:

Tetrahydropyranyl vinyl ether; With lithiating reagent;

(E)-2-methyl-1-morpholin-4-yl-3-phenylprop-2-en-1-one; In tetrahydrofuran; at -78 - -30 ℃;

DOI:10.1021/ol050970x

Reference yield: 77.0%

Tetrahydropyranyl vinyl ether (22408-41-9) → 2-(tetrahydropyran-2-yl)ethanol (38786-79-7)

Guidance literature:

With triisobutylaluminum; In hexane; 1.) RT, 30 min, 2.) 60 deg C, 5 h;

DOI:10.1021/jo00235a010

upstream raw materials:

2-(2-bromoethoxy)tetrahydropyran

Downstream raw materials:

2-(tetrahydropyran-2-yl)ethanol

Refernces