38786-79-7Relevant academic research and scientific papers
Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase
Ekkati, Anil R.,Bollini, Mariela,Domaoal, Robert A.,Spasov, Krasimir A.,Anderson, Karen S.,Jorgensen, William L.
scheme or table, p. 1565 - 1568 (2012/03/26)
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase is being pursued with computational guidance. Extension of azine-containing inhibitors into the entrance channel between Lys103 and Glu138 has led to the discovery of potent and structurally novel derivatives including dimeric inhibitors in an NNRTI-linker-NNRTI motif.
AZAINDOLE GLUCOKINASE ACTIVATORS
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, (2011/06/26)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
PURINE DERIVATIVES AS IMMUNOMODULATORS
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Page/Page column 90, (2008/12/08)
The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants
A novel synthesis of the north west portion of Lasonolide A - An anticancer macrolide using Claisen rearrangement
Kar, Paramita,Rao,Nagaiah,Gurjar
, p. 52 - 54 (2007/10/03)
A simplified analogue of Lasonolide A (C23-C35 side chain) was synthesized using Fujisawa's stereoselective variant of the Ireland Claisen ester rearrangement.
Triisobutylaluminum-Assisted Reductive Rearrangement of Alkyl 1-Alkenyl Acetals: An Easy Synthesis of β-Alkoxy Alcohols
Menicagli, R.,Malanga, C.,Dell'Innocenti, M.,Lardicci, L.
, p. 5700 - 5704 (2007/10/02)
Alkyl 1-alkenyl acetals react with Al-i-Bu3 to give very good yields of β-alkoxy alcohols through a reductive rearrangement.The reaction is totally regioselective, but no stereocontrol occurs.
