tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate
CAS No.:1621401-10-2
Molecular Formula:C₂₃H₃₂N₂O₄
Molecular Weight:400.518
Hs Code.:

Synonyms:tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate

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Chemical Property of tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate

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Technology Process of tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate

There total 3 articles about tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 121778-75-4
N-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-ethylamine

: 100-10-7
4-dimethylamino-benzaldehyde

: 1621401-10-2
tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate

Guidance literature:: N-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-ethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -20 - 0 ℃; for 2h; Inert atmosphere;

4-dimethylamino-benzaldehyde; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 2h; Enzymatic reaction;
DOI:10.1055/s-0033-1338570

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 1621401-10-2
tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Enzymatic reaction

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-0033-1338570

Reference yield:

: 104-47-2
p-methoxybenzylnitrile

: 1621401-10-2
tert-butyl (2-{2-[(4-(dimethylamino)phenyl)(hydroxy)methyl]-4-methoxyphenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0 - 20 °C

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Enzymatic reaction

With aluminum (III) chloride; lithium aluminium tetrahydride; n-butyllithium; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1055/s-0033-1338570