Technology Process of graphisin A
There total 13 articles about graphisin A which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol; water;
at 45 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol301107m
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 0.08 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 8 h / 20 °C / Inert atmosphere
4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere
5.1: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 0 - 20 °C / Inert atmosphere
6.1: methanol; hexane / 0.33 h / 0 °C / Inert atmosphere
7.1: toluene-4-sulfonic acid / methanol; water / 3 h / 45 °C / Inert atmosphere
With
sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; palladium 10% on activated carbon; hydrogen; tert.-butyl lithium; Dess-Martin periodane; toluene-4-sulfonic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol; pentane;
4.1: Dess-Martin oxidation / 5.1: Pinnick oxidation;
DOI:10.1021/ol301107m
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere
2: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 0 - 20 °C / Inert atmosphere
3: methanol; hexane / 0.33 h / 0 °C / Inert atmosphere
4: toluene-4-sulfonic acid / methanol; water / 3 h / 45 °C / Inert atmosphere
With
sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; Dess-Martin periodane; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; tert-butyl alcohol;
1: Dess-Martin oxidation / 2: Pinnick oxidation;
DOI:10.1021/ol301107m
