N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide

Base Information

• Chemical Name: N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide
• CAS No.: 1612232-09-3
• Molecular Formula: C₁₈H₁₈ClNOS₂
• Molecular Weight: 363.932
• Mol file: 1612232-09-3.mol

Synonyms:N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide

Chemical Property of N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide

There total 1 articles about N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H14ClNOS2 + methyl iodide (74-88-4) → N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide (1612232-09-3)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.25h;

DOI:10.1002/anie.201310340

Reference yield: 82.0%

N-benzyl-2-(4-chlorophenyl)-3,3-bis(methylthio)acrylamide (1612232-09-3) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 1-benzyl-3-(4-chlorophenyl)-4-(methylthio)quinolin-2(1H)-one (1612231-77-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; cesium fluoride; In toluene; acetonitrile; at 80 ℃; for 18h; Glovebox; Sealed tube;

DOI:10.1002/anie.201310340

upstream raw materials:

methyl iodide

Downstream raw materials:

1-benzyl-3-(4-chlorophenyl)-4-(methylthio)quinolin-2(1H)-one