5-PHENYL-1,2,4-THIADIAZOL-3-AMINE

Base Information

• Chemical Name: 5-PHENYL-1,2,4-THIADIAZOL-3-AMINE
• CAS No.: 27182-54-3
• Molecular Formula: C8H7N3S
• Molecular Weight: 177.23
• Hs Code.: 2934999090
• Mol file: 27182-54-3.mol

Synonyms:5-Phenyl-1,2,4-thiadiazol-3-amine;1,2,4-Thiadiazole,3-amino-5-phenyl- (6CI,7CI,8CI);3-Amino-5-phenyl-1,2,4-thiadiazole;

Chemical Property of 5-PHENYL-1,2,4-THIADIAZOL-3-AMINE

Chemical Property:

• Vapor Pressure: 2.45E-05mmHg at 25°C
• Melting Point: 136 °C
• Refractive Index: 1.669
• Boiling Point: 359 °C at 760 mmHg
• PKA: 1.48±0.11(Predicted)
• Flash Point: 170.9 °C
• PSA: 80.04000
• Density: 1.333 g/cm³
• LogP: 2.36850
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-phenyl-1,2,4-thiadiazol-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PHENYL-1,2,4-THIADIAZOL-3-AMINE

There total 11 articles about 5-PHENYL-1,2,4-THIADIAZOL-3-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-bromo-5-phenyl-1,2,4-thiadiazole (101495-43-6) → 5-phenyl-1,2,4-thiadiazol-3-amine (27182-54-3)

Guidance literature:

3-bromo-5-phenyl-1,2,4-thiadiazole; With lithium hexamethyldisilazane; In tetrahydrofuran; for 1h;

With water; In tetrahydrofuran; for 3h;

DOI:10.1021/ol902371y

Reference yield: 22.0%

N-carbamoyl-N'-thiobenzoylguanidine (89880-02-4) → 5-phenyl-1,2,4-thiadiazol-3-amine (27182-54-3) + N-(5-phenyl-1,2,4-thiadiazol-3-yl)urea (89880-03-5)

Guidance literature:

With di-(p-methoxyphenyl)tellurium oxide; In ethanol; for 1h; Ambient temperature;

Reference yield:

3-(Acetylamino)-4-phenylfurazan (10349-15-2) → 5-phenyl-1,2,4-thiadiazol-3-amine (27182-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / Lawesson reagent / toluene / 0.5 h / Heating

2: PCl₅ / CHCl₃ / 3 h / Ambient temperature

With Lawessons reagent; phosphorus pentachloride; In chloroform; toluene;

upstream raw materials:

benzoylcarbamimidoyl-thiourea

Thiobenzoic acid O-ethyl ester

acetylguanidine

benzoylguanidine

Downstream raw materials:

N-acetyl-sulfanilic acid-(5-phenyl-[1,2,4]thiadiazol-3-ylamide)

4-acetylamino-N-(5-phenyl-[1,2,4]thiadiazol-3-ylcarbamoyl)-benzenesulfonamide

(5-phenyl-[1,2,4]thiadiazol-3-yl)-carbamic acid ethyl ester

(5-phenyl-[1,2,4]thiadiazol-3-yl)-trityl-amine