89880-02-4

Upstream product

• 7746-72-7 N¹-benzoyl-N³-cyanoguanidine 
• 7746-72-7 Benzoyldicyandiamid 

Downstream Products

• 27182-54-3 5-phenyl-1,2,4-thiadiazol-3-amine 
• 89880-03-5 N-(5-phenyl-1,2,4-thiadiazol-3-yl)urea 
• 5378-17-6 3-hydroxy-5-phenyl-1,2,4-thiadiazole 
• 89879-89-0 (E)-2-(5-Phenyl-[1,2,4]thiadiazol-3-yloxy)-but-2-enedioic acid dimethyl ester 
• 89879-90-3 (Z)-2-(5-Phenyl-[1,2,4]thiadiazol-3-yloxy)-but-2-enedioic acid dimethyl ester 
• 89879-95-8 5-phenyl-3--1,2,4-thiadiazole 
• 89879-85-6 2-methyl-5-phenyl-1,2,4-thiadiazol-3(2H)-one 
• 3201-53-4 N-[(methylamino)carbonyl]benzamide 
• 89879-86-7 3-methoxy-5-phenyl-1,2,4-thiadiazole 

Relevant academic research and scientific papers

A New Ring Interconversion: 3-Azido-1,2,4-thiadiazoles from the Reaction of Thionyl Chloride with 1-Alkyl-5-aminotetrazoles

Heating of some 1-alkyl-5-aminotetrazoles with thionyl chloride gave 3-azido-1,2,4-thiadiazoles in a reaction involving 5-N-sulphinylaminotetrazoles as intermediates.

Cyclic Meso-ionic Compounds. Part 23. Novel Chemistry of 1,2,4-Thiadiazoles and Their Transformation into Meso-ionic 1,2,4-Thiadiazolium Derivatives

Representatives of two new classes of meso-ionic heterocycles have been synthesised, the 1,2,4-thiadiazolium-3-olate (8) and the 1,2,4-thiadiazolium-3-tosylaminide (25).The reactions of 1,2,4-thiadiazoles and nucleophiles follow two general pathways: (i) reductive transformation to N-thiobenzoyl derivatives and (ii) elimination of elemental sulphur and the formation of N-benzoyl derivatives.A mechanistic rationale is proposed for the operation of pathways (i) and (ii).Earlier views on the oxidative formation of certain 1,2,4-thiadiazoles are corrected.A novel synthetic route to heterocycles containing sulphur-nitrogen bonds is described. 1,2,4-Thiadiazoles are formed by oxidation of N-thiobezoylureas and N-thiobenzoylguanidines by bis(4-methoxyphenyl) telluroxide.