2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

Base Information

• Chemical Name: 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid
• CAS No.: 1262007-59-9
• Molecular Formula: C₂₆H₂₆F₃NO₄
• Molecular Weight: 473.492
• Mol file: 1262007-59-9.mol

Synonyms:2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

Chemical Property of 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

There total 7 articles about 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate (1262008-54-7) → 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid (1262007-59-9)

Guidance literature:

With rac-cysteine; trifluoroacetic acid; at 23 ℃; for 0.25h;

Reference yield:

tert-butyl 2-(8-(benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate (1262008-52-5) → 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid (1262007-59-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C / sealed scintillation vial

3: trifluoroacetic acid; rac-cysteine / 0.25 h / 23 °C

With rac-cysteine; ammonium formate; potassium carbonate; trifluoroacetic acid; 20 % Pd(OH)2/C; In methanol; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 3-(5-(benzyloxy)-1H-indol-2-yl)acrylate → 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid (1262007-59-9)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 80 °C / sealed tube

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: cesium fluoride / tetrahydrofuran / 100 °C / sealed tube

4: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C / sealed scintillation vial

6: trifluoroacetic acid; rac-cysteine / 0.25 h / 23 °C

With rac-cysteine; tetrabutyl ammonium fluoride; ammonium formate; sodium hydride; potassium carbonate; cesium fluoride; trifluoroacetic acid; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

tert-butyl 2-(8-(benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

tert-butyl 2-(8-hydroxy-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

tert-butyl 3-(5-(benzyloxy)-1-(2-hydroxyethyl)-1H-indol-2-yl)acrylate

Downstream raw materials:

2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid