tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate
CAS No.:1262008-54-7
Molecular Formula:C₃₀H₃₄F₃NO₄
Molecular Weight:529.599
Hs Code.:

Synonyms:tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Chemical Property of tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Technology Process of tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

There total 7 articles about tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957208-65-0
4-(chloromethyl)-1-cyclopentyl-2-(trifluoromethyl)benzene

: 1262008-53-6
tert-butyl 2-(8-hydroxy-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262008-54-7
tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h; sealed scintillation vial;

Reference yield:

: 1262008-52-5
tert-butyl 2-(8-(benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262008-54-7
tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C / sealed scintillation vial

With ammonium formate; potassium carbonate; 20 % Pd(OH)2/C; In methanol; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl 3-(5-(benzyloxy)-1H-indol-2-yl)acrylate

: 1262008-54-7
tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 80 °C / sealed tube

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: cesium fluoride / tetrahydrofuran / 100 °C / sealed tube

4: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C / sealed scintillation vial

With tetrabutyl ammonium fluoride; ammonium formate; sodium hydride; potassium carbonate; cesium fluoride; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;