(+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:(+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:131567-11-8
Molecular Formula:C₁₇H₁₇BrClNO
Molecular Weight:366.685
Hs Code.:

Synonyms:(+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of (+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of (+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 9 articles about (+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 131567-09-4
(+/-)-7-chloro-8-methoxy-1-(3'-bromophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 131567-11-8
(+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With boron tribromide; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00107a002

Reference yield:

: 7569-87-1
3-chloro-4-methoxyphenethylamine

: 131567-11-8
(+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1.2: 95 percent / BH₃ / tetrahydrofuran

2.1: 90 percent / xylene / Heating

3.1: H₂SO₄ / 0 °C

4.1: BBr₃

With sulfuric acid; boron tribromide; In xylene; 1.1: Formylation / 1.2: Reduction / 2.1: Ring cleavage / 3.1: Cyclization / 4.1: demethylation;
DOI:10.1016/S0960-894X(00)00185-2

Reference yield:

: 28022-44-8,131567-05-0
2-(3-bromophenyl)oxirane

: 131567-11-8
(+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent

2: H₂SO₄ / 2 h / 0 - 20 °C

3: HCO₂H / H₂O / 4 h / 90 - 100 °C

4: 49 percent / BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

With formic acid; sulfuric acid; boron tribromide; In dichloromethane; water;
DOI:10.1021/jm00107a002