2-Chloro-4-(chloromethyl)-1-methoxybenzene

Base Information

• Chemical Name: 2-Chloro-4-(chloromethyl)-1-methoxybenzene
• CAS No.: 13719-57-8
• Molecular Formula: C8H8 Cl2 O
• Molecular Weight: 191.057
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID40457216
• Nikkaji Number: J1.325.210F
• Wikidata: Q82279979
• Mol file: 13719-57-8.mol

Synonyms:2-chloro-4-(chloromethyl)-1-methoxybenzene;13719-57-8;3-CHLORO-4-METHOXYBENZYL CHLORIDE;SCHEMBL4976340;DTXSID40457216;JAXSPAXDDROBLQ-UHFFFAOYSA-N;1-Methoxy-2-chloro-4-(chloromethyl)benzene;EN300-116796;N12801;A921055

Chemical Property of 2-Chloro-4-(chloromethyl)-1-methoxybenzene

Chemical Property:

• Melting Point: 38 °C
• Boiling Point: 150-200 °C(Press: 12 Torr)
• PSA: 9.23000
• Density: 1.248±0.06 g/cm3(Predicted)
• LogP: 3.08740
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 189.9952203
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-4-(chloromethyl)-1-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CCl)Cl

Technology Process of 2-Chloro-4-(chloromethyl)-1-methoxybenzene

There total 5 articles about 2-Chloro-4-(chloromethyl)-1-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-chloro-4-methoxybenzyl alcohol (14503-45-8) → 3-chloro-4-methoxybenzyl chloride (13719-57-8)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; Reflux;

Reference yield: 61.0%

3-chloro-4-methoxybenzyl alcohol (14503-45-8) + methanesulfonyl chloride (124-63-0) → 3-chloro-4-methoxybenzyl chloride (13719-57-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; ethyl acetate;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Chloroanisole (766-51-8) → 3-chloro-4-methoxybenzyl chloride (13719-57-8)

Guidance literature:

With hydrogenchloride; at 96 ℃;

upstream raw materials:

formaldehyd

2-Chloroanisole

3-chloro-4-methoxybenzyl alcohol

3-chloro-4-methoxy-benzaldehyde

Downstream raw materials:

2-(3-chloro-4-methoxyphenyl)acetonitrile

6-(3-Chloro-4-methoxy-phenyl)-5-(4-chloro-phenyl)-2,2-dimethyl-hexan-3-one

3-chloro-4-(3'-chloro-4'-methoxybenzyloxy)-phenylacetic acid

6-(3-Chloro-4-methoxy-phenyl)-5-(3,4-dichloro-phenyl)-2,2-dimethyl-hexan-3-one