{2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

Base Information

Chemical Name:{2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid
CAS No.:1082741-24-9
Molecular Formula:C₁₈H₂₅N₆O₅P
Molecular Weight:436.407
Hs Code.:

Synonyms:{2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

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Chemical Property of {2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

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Technology Process of {2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

There total 9 articles about {2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1082741-23-8
{2-[6-amino-2-(4-butyl-3-hydroxy-phenylamino)-purin-9-yl]-ethoxymethyl}-phosphonic acid diethyl ester

: 1082741-24-9
{2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

Guidance literature:: With trimethylsilyl bromide; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

: 2-[3-(tert-butyldiphenylsiloxy)-4-butylphenylamino]-1,4,5,9-tetrahydropurin-6-one

: 1082741-24-9
{2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

1.2: 15.25 h / 0 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 17 h / 70 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 20 °C

4.1: ammonia / methanol / 15 h / 85 °C / Autoclave

5.1: trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

With trimethylsilyl bromide; tetrabutyl ammonium fluoride; tetrabutyl-ammonium chloride; ammonia; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

: 28583-62-2
N-(4-butyryl-3-hydroxyphenyl)acetamide

: 1082741-24-9
{2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: palladium on activated charcoal; methanesulfonic acid; hydrogen; acetic acid / ethanol; ethyl acetate

2.1: potassium hydroxide / methanol; water / 3.5 h / 100 °C

3.1: pyridine; dmap / methanol / 144 h / Heating

4.1: ethyl methyl ether; water / 16 h / 125 °C

5.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

5.2: 15.25 h / 0 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 17 h / 70 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 20 °C

8.1: ammonia / methanol / 15 h / 85 °C / Autoclave

9.1: trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

With pyridine; dmap; methanesulfonic acid; trimethylsilyl bromide; palladium on activated charcoal; tetrabutyl ammonium fluoride; tetrabutyl-ammonium chloride; ammonia; hydrogen; acetic acid; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; ethyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ijpharm.2010.06.036