[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Base Information

• Chemical Name: [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine
• CAS No.: 1252577-08-4
• Molecular Formula: C₃₁H₃₄ClN₅OSi
• Molecular Weight: 556.182
• Mol file: 1252577-08-4.mol

Synonyms:[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Chemical Property of [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

There total 6 articles about [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-[3-(tert-butyldiphenylsiloxy)-4-butylphenylamino]-1,4,5,9-tetrahydropurin-6-one → [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine (1252577-08-4)

Guidance literature:

2-[3-(tert-butyldiphenylsiloxy)-4-butylphenylamino]-1,4,5,9-tetrahydropurin-6-one; With tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In acetonitrile; at 110 ℃; for 8.5h;

With sodium acetate; In acetonitrile; at 0 ℃; for 15.25h;

DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

C26H33NOSi (1252577-13-1) → [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine (1252577-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethyl methyl ether; water / 16 h / 125 °C

2.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

2.2: 15.25 h / 0 °C

With tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In ethyl methyl ether; water; acetonitrile;

DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

N-(4-butyl-3-hydroxyphenyl)acetamide (22932-84-9) → [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine (1252577-08-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol; water / 3.5 h / 100 °C

2.1: pyridine; dmap / methanol / 144 h / Heating

3.1: ethyl methyl ether; water / 16 h / 125 °C

4.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

4.2: 15.25 h / 0 °C

With pyridine; dmap; tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; potassium hydroxide; trichlorophosphate; In methanol; ethyl methyl ether; water; acetonitrile;

DOI:10.1016/j.ijpharm.2010.06.036

upstream raw materials:

C₂₆H₃₃NOSi

N-(4-butyryl-3-hydroxyphenyl)acetamide

N-(4-butyl-3-hydroxyphenyl)acetamide

3-acetamidophenyl butyrate

Downstream raw materials:

{2-[6-chloro-2-(4-butyl-3-hydroxyphenylamino)-purin-9-yl]-ethoxymethyl}-phosphonic acid diethyl ester

{2-[6-amino-2-(4-butyl-3-hydroxyphenylamino)-purine-9-yl]-ethoxymethyl}-phosphonic acid

{2-[6-amino-2-(4-butyl-3-hydroxy-phenylamino)-purin-9-yl]-ethoxymethyl}-phosphonic acid diethyl ester

(2-{2-[3-(tert-butyldiphenylsiloxy)-4-butyl-phenylamino]-6-chloro-purin-9-yl}-ethoxymethyl)-phosphonic acid diethyl ester