[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Base Information

Chemical Name:[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine
CAS No.:1252577-08-4
Molecular Formula:C₃₁H₃₄ClN₅OSi
Molecular Weight:556.182
Hs Code.:

Synonyms:[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

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Chemical Property of [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

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Technology Process of [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

There total 6 articles about [3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 2-[3-(tert-butyldiphenylsiloxy)-4-butylphenylamino]-1,4,5,9-tetrahydropurin-6-one

: 1252577-08-4
[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Guidance literature:: 2-[3-(tert-butyldiphenylsiloxy)-4-butylphenylamino]-1,4,5,9-tetrahydropurin-6-one; With tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In acetonitrile; at 110 ℃; for 8.5h;

With sodium acetate; In acetonitrile; at 0 ℃; for 15.25h;
DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

: 1252577-13-1
C₂₆H₃₃NOSi

: 1252577-08-4
[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl methyl ether; water / 16 h / 125 °C

2.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

2.2: 15.25 h / 0 °C

With tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In ethyl methyl ether; water; acetonitrile;
DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

: 22932-84-9
N-(4-butyl-3-hydroxyphenyl)acetamide

: 1252577-08-4
[3-(tert-butyldiphenylsiloxy)-4-butylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol; water / 3.5 h / 100 °C

2.1: pyridine; dmap / methanol / 144 h / Heating

3.1: ethyl methyl ether; water / 16 h / 125 °C

4.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

4.2: 15.25 h / 0 °C

With pyridine; dmap; tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; potassium hydroxide; trichlorophosphate; In methanol; ethyl methyl ether; water; acetonitrile;
DOI:10.1016/j.ijpharm.2010.06.036