3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

Base Information

Chemical Name:3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one
CAS No.:1335016-51-7
Molecular Formula:C₂₆H₂₄N₄O₄S
Molecular Weight:488.567
Hs Code.:

Synonyms:3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

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Chemical Property of 3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

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Technology Process of 3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

There total 7 articles about 3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1335015-36-5
2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

: 74-88-4
methyl iodide

: 1335016-51-7
3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;
DOI:10.1016/j.ejmech.2011.05.061

Reference yield:

: 374711-37-2
4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoic acid

: 1335016-51-7
3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; chloroform / 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 100 °C

3.2: 16 h / 100 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2011.05.061

Reference yield:

: 1335014-00-0
tert-butyl 4-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoyl)piperazine-1-carboxylate

: 1335016-51-7
3-methyl-2-(4-(4-(phenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; chloroform / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 100 °C

2.2: 16 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

With hydrogenchloride; sodium hydride; potassium carbonate; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2011.05.061