3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Base Information

Chemical Name:3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide
CAS No.:1070294-42-6
Molecular Formula:C₂₈H₂₄N₂O₃
Molecular Weight:436.51
Hs Code.:

Synonyms:3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

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Chemical Property of 3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

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Technology Process of 3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

There total 7 articles about 3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070292-58-8
3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1070294-42-6
3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.166667h;

3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide; at 80 ℃; for 6h;

With water; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070294-42-6
3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: lithium hydroxide; water / methanol / 3 h / 20 - 50 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C

5.1: dichloromethane / 12 h / 20 °C

6.1: trichlorophosphate / 0.17 h / 0 °C

6.2: 6 h / 80 °C

6.3: 0.17 h / 0 °C

With lithium hydroxide; oxalyl dichloride; water; sodium hydride; potassium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1070292-54-4
4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester

: 1070294-42-6
3-(2-benzyl-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: lithium hydroxide; water / methanol / 3 h / 20 - 50 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C

4.1: dichloromethane / 12 h / 20 °C

5.1: trichlorophosphate / 0.17 h / 0 °C

5.2: 6 h / 80 °C

5.3: 0.17 h / 0 °C

With lithium hydroxide; oxalyl dichloride; water; sodium hydride; trichlorophosphate; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;