3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Base Information

Chemical Name:3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide
CAS No.:1070292-58-8
Molecular Formula:C₂₇H₂₄N₂O₂
Molecular Weight:408.5
Hs Code.:

Synonyms:3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

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Chemical Property of 3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Chemical Property:

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Technology Process of 3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

There total 6 articles about 3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070292-57-7
3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoyl chloride

: 765-30-0
Cyclopropylamine

: 1070292-58-8
3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070292-58-8
3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: lithium hydroxide; water / methanol / 3 h / 20 - 50 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C

5.1: dichloromethane / 12 h / 20 °C

With lithium hydroxide; oxalyl dichloride; water; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1070292-54-4
4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester

: 1070292-58-8
3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: lithium hydroxide; water / methanol / 3 h / 20 - 50 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C

4.1: dichloromethane / 12 h / 20 °C

With lithium hydroxide; oxalyl dichloride; water; sodium hydride; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;