4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine

Base Information

• Chemical Name: 4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine
• CAS No.: 124881-54-5
• Molecular Formula: C₁₃H₁₅N₅O₂
• Molecular Weight: 273.294
• Mol file: 124881-54-5.mol

Synonyms:4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine

Chemical Property of 4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine

There total 2 articles about 4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,2,3,4-Tetrahydro-6-methyl-2-oxo-4-thio-5-p-tolylcarbamoylpyrimidine (124881-48-7) → 4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine (124881-54-5)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1002/ardp.19893221006

Reference yield:

6-methyl-2-oxo-4-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (51622-66-3) → 4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine (124881-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / DCC / dimethylformamide

2: 85 percent / 80percent N₂H₄*H₂O / ethanol / Heating

With hydrazine hydrate; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/ardp.19893221006

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-Hydrazino-1,2-dihydro-6-methyl-2-oxo-5-p-tolylcarbamoylpyrimidine (124881-54-5) → 1,3,4,10-Tetrahydro-6-methyl-4-p-tolyl-1,2,4-triazolo<2,3,4-c,d>pyrimido<4,5-d>pyrimidine-5,8-dione

Guidance literature:

With pyridine; Yield given. Multistep reaction; 1.) aq. EtOH, reflux, 2.) reflux;

DOI:10.1002/ardp.19893221006

upstream raw materials:

1,2,3,4-Tetrahydro-6-methyl-2-oxo-4-thio-5-p-tolylcarbamoylpyrimidine

6-methyl-2-oxo-4-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid