(Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile

Base Information

• Chemical Name: (Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile
• CAS No.: 1262120-73-9
• Molecular Formula: C₁₇H₁₂N₂O₂
• Molecular Weight: 276.294
• Mol file: 1262120-73-9.mol

Synonyms:(Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile

Chemical Property of (Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile

There total 3 articles about (Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(E)-3-(4‘-methoxybenzylidene)indolin-2-one (29551-48-2) + trimethylsilyl cyanide (7677-24-9) → (Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile (1262120-73-9)

Guidance literature:

With cerium(III) chloride heptahydrate; potassium hydroxide; In water; at 100 ℃; for 2h; Green chemistry;

DOI:10.1080/00397911.2018.1540050

Reference yield: 84.0%

benzoyl cyanide (613-90-1) + (E)-3-(4‘-methoxybenzylidene)indolin-2-one (29551-48-2) → (Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile (1262120-73-9)

Guidance literature:

With potassium carbonate; potassium hydroxide; In water; acetonitrile; at 80 ℃; for 3h; stereoselective reaction;

DOI:10.1016/j.tet.2018.01.050

Reference yield:

copper(l) cyanide + C16H11NO2 → (Z)-2-(4-methoxyphenyl)-2-(2-oxoindolin-3-ylidene)acetonitrile (1262120-73-9) + C17H12N2O2

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; In 1,4-dioxane; at 100 ℃; for 2h; optical yield given as %de; stereoselective reaction;

DOI:10.1246/cl.2010.1132

upstream raw materials:

benzoyl cyanide

(E)-3-(4‘-methoxybenzylidene)indolin-2-one

trimethylsilyl cyanide