1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione

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Chemical Name:1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione
CAS No.:123169-17-5
Molecular Formula:C₂₄H₂₅FN₂O₄
Molecular Weight:424.472
Hs Code.:

Synonyms:1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione

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Chemical Property of 1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione

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Technology Process of 1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione

There total 3 articles about 1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 123169-19-7
1-((1R,2R,3S,4R)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-3-((E)-3-ethoxy-acryloyl)-urea

: 123169-17-5
1-<<1R-(1α,2β,3α,4β)>-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-2-fluoro-1-cyclopentyl>-2,4-(1H,3H)-pyrimidinedione

Guidance literature:: With sulfuric acid; In 1,4-dioxane; for 1.25h; Heating;
DOI:10.1021/jm00163a030

Reference yield:

: 110567-23-2
(1S,2S,3S,5S)-5-azido-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol

: 123169-17-5
1-((1S,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: diethylaminosulphur trifluoride, H₂ / Lindlar cat. / 1.) CH₂Cl₂

2: H₂SO₄, H₂ / Pd/C / 1.) C₆H₆, 5 deg C; 2.) dioxane, water, reflux; 3.) EtOH

With diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; palladium on activated charcoal; Lindlar catalyst;
DOI:10.1039/C39870000255

Reference yield:

: 110567-26-5
<1S-(1α,2β,3α,4β)>-2-fluoro-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-cyclopentanamine

: 2-methyl-3-ethoxyacryloyl isocyanate

: 123169-17-5
1-((1S,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-fluoro-cyclopentyl)-1H-pyrimidine-2,4-dione

Guidance literature:: With sulfuric acid; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction; 1.) C₆H₆, 5 deg C; 2.) dioxane, water, reflux; 3.) EtOH;
DOI:10.1039/C39870000255