ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate

Base Information

• Chemical Name: ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate
• CAS No.: 1335465-69-4
• Molecular Formula: C₂₄H₂₄Cl₂FN₃O₆
• Molecular Weight: 540.375
• Mol file: 1335465-69-4.mol

Synonyms:ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate

Chemical Property of ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate

There total 8 articles about ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-fluoroethoxy)aniline (1764-82-5) → ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate (1335465-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/jlcr.1901

Reference yield:

4,6-dichloro-3-(methoxycarbonylmethylimino-methyl)-1H-indole-2-carboxylic acid ethyl ester → ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate (1335465-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 1.5 h / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; In dichloromethane;

DOI:10.1002/jlcr.1901

Reference yield:

ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate (103855-01-2) → ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate (1335465-69-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: polyphosphoric acid / 0.17 h / 70 - 130 °C

2.1: trichlorophosphate / 20 °C / Inert atmosphere

2.2: 8 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 1.5 h / Inert atmosphere

5.1: dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; triethylamine; trichlorophosphate; In dichloromethane; 1.1: Fischer indole synthesis / 2.2: Vilsmeier formylation;

DOI:10.1002/jlcr.1901

upstream raw materials:

ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate

1-(2-fluoroethoxy)-3-nitrobenzene

meta-nitrophenol

4,6-dichloro-indole-2-carboxylic acid,ethyl ester

Downstream raw materials:

ethyl 4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate

4,6-dichloro-3-((3-(3-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid