5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

Base Information

Chemical Name:5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole
CAS No.:171780-61-3
Molecular Formula:C₂₂H₂₆N₂O₅S
Molecular Weight:430.525
Hs Code.:

Synonyms:5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

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Chemical Property of 5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

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Technology Process of 5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

There total 1 articles about 5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171780-60-2
(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-(3-methyl-2-phenylsulfanyl-3H-imidazol-4-yl)-methanol

: 74-88-4
methyl iodide

: 171780-61-3
5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

Guidance literature:: With sodium hydride; Yield given;
DOI:10.1016/0040-4039(95)01770-I

Reference yield: 59.0%

: 171780-61-3
5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

: 171780-62-4
4-Bromo-5-[(3,4-dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; at -30 ℃; for 3h;
DOI:10.1248/cpb.45.1393

Reference yield:

: 171780-61-3
5-[(3,4-Dimethoxy-2-methoxymethoxy-phenyl)-methoxy-methyl]-1-methyl-2-phenylsulfanyl-1H-imidazole

: 171780-66-8
8-(tert-Butyl-dimethyl-silanyloxy)-6,7-dimethoxy-4-(4-methoxy-phenyl)-1-methyl-1,3-dihydro-naphtho[2,3-d]imidazol-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 59 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / -30 °C

2: 1.) t-BuLi / 1.) pentane, ether, 23 deg C, 2 min, 2.) pentane, ether, -78 deg C, 1 h

3: 99 percent / polyphosphoric acid / 0.08 h / 0 °C

4: 100 percent / NaBH₄, NiCl₂*6H₂O / methanol; tetrahydrofuran / 1 h / 0 °C

5: aq. Na₂CO₃ / methanol / 1 h / Ambient temperature

6: imidazole / dimethylformamide / 12 h / 60 °C

7: 1.) LDA, 2.) (PhCH₂OCOO)2 / 1.) n-hexane, THF, -78 deg C, 2 h, 2.) n-hexane, THF, RT, 1 h

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; PPA; dibenzyl peroxydicarbonate; tert.-butyl lithium; sodium carbonate; nickel dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1393