(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

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Chemical Name:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide
CAS No.:1286280-43-0
Molecular Formula:C₂₁H₂₈N₂O₂S
Molecular Weight:372.532
Hs Code.:

Synonyms:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

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Chemical Property of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

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Technology Process of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

There total 11 articles about (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1286280-79-2
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

: 1286280-43-0
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

Guidance literature:: With hydrazine hydrate; In ethanol; at 60 ℃;

Reference yield:

: 36438-64-9
p-benzyloxystyrene

: 1286280-43-0
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; tert-butylhypochlorite / water; propan-1-ol / 0.08 h / 20 °C

1.2: 0.1 h / Cooling with ice

1.3: 1.5 h / 0 °C

2.1: hydrogen / palladium on carbon / dichloromethane; ethanol / 20 °C / 760.05 Torr

3.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

6.1: triethylamine / dichloromethane / 20 °C

7.1: hydrazine hydrate / ethanol / 60 °C

With hydrazine hydrate; tert-butylhypochlorite; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium on carbon; In tetrahydrofuran; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1286280-43-0
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C

2.1: sodium hydroxide; tert-butylhypochlorite / water; propan-1-ol / 0.08 h / 20 °C

2.2: 0.1 h / Cooling with ice

2.3: 1.5 h / 0 °C

3.1: hydrogen / palladium on carbon / dichloromethane; ethanol / 20 °C / 760.05 Torr

4.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

7.1: triethylamine / dichloromethane / 20 °C

8.1: hydrazine hydrate / ethanol / 60 °C

With n-butyllithium; hydrazine hydrate; tert-butylhypochlorite; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium on carbon; In tetrahydrofuran; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Mitsunobu reaction;