(2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide

Base Information

• Chemical Name: (2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide
• CAS No.: 637362-80-2
• Molecular Formula: C₂₀H₂₅N₅O
• Molecular Weight: 351.451

Synonyms:(2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide

Chemical Property of (2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide

Chemical Property:

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Technology Process of (2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide

There total 4 articles about (2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + (2S)-2-amino-4-methyl-N-(4-methylphenyl)pentanamide (372187-67-2) → (2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide (637362-80-2)

Guidance literature:

In methanol; water; at 25 ℃; for 12h;

DOI:10.1021/jo026622f

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → (2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide (637362-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1: CF₃CO₂H / CH₂Cl₂

2: 93 percent / methanol; H₂O / 12 h / 25 °C

With trifluoroacetic acid; In methanol; dichloromethane; water;

DOI:10.1021/jo026622f

Reference yield:

p-toluidine (106-49-0,12221-03-3) → (2S)-2-[(1H-benzotriazol-1-ylmethyl)amino]-4-methyl-N-(4-methylphenyl)pentanamide (637362-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1: CF₃CO₂H / CH₂Cl₂

2: 93 percent / methanol; H₂O / 12 h / 25 °C

With trifluoroacetic acid; In methanol; dichloromethane; water;

DOI:10.1021/jo026622f

upstream raw materials:

1,2,3-Benzotriazole

formaldehyd

(2S)-2-amino-4-methyl-N-(4-methylphenyl)pentanamide

N-tert-butoxycarbonyl-L-leucine

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