methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate

Base Information

Chemical Name:methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate
CAS No.:1117749-58-2
Molecular Formula:C₂₆H₁₉FN₄O₅
Molecular Weight:486.459
Hs Code.:

Synonyms:methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate

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Chemical Property of methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate

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Technology Process of methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate

There total 12 articles about methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 503614-64-0
methyl [2-fluoro-4-(2-oxo-1(2H)-pyridinyl)-phenyl]acetate

: 3-cyano-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxylic 2,2-dimethylpropanoic anhydride

: 1117749-58-2
methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate

Guidance literature:: methyl [2-fluoro-4-(2-oxo-1(2H)-pyridinyl)-phenyl]acetate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.333333h;

3-cyano-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxylic 2,2-dimethylpropanoic anhydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 - 23 ℃; for 12h;

Reference yield:

: 503614-64-0
methyl [2-fluoro-4-(2-oxo-1(2H)-pyridinyl)-phenyl]acetate

: 1117749-58-2
methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate

Guidance literature:: With n-butyllithium; 4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.11.040

Reference yield:

: C₁₅H₁₁ClN₂O₃

: 1117749-58-2
methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; ammonia / 1,4-dioxane; dichloromethane / 0.5 h

2.1: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 0.7 h

3.1: potassium permanganate; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.17 h / 60 °C

4.1: triethylamine / diethyl ether / 1.5 h / 23 °C

5.1: n-butyllithium; diisopropylamine / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.33 h / -78 °C

5.2: 12 h / -78 - 23 °C

With pyridine; potassium permanganate; sodium dihydrogenphosphate; n-butyllithium; ammonia; triethylamine; diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; tert-butyl alcohol;