5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

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Chemical Name:5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide
CAS No.:503613-35-2
Molecular Formula:C₂₄H₁₉FN₄O₄
Molecular Weight:446.438
Hs Code.:

Synonyms:5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

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Chemical Property of 5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

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Technology Process of 5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

There total 15 articles about 5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 503614-73-1
5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carbonitrile

: 503613-35-2
5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

Guidance literature:: With sulfuric acid; water; for 2h;

Reference yield: 41.0%

: 67-56-1
methanol

: concentrated aqueous dihydrogen sulfate

: 503614-73-1
5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carbonitrile

: 503613-35-2
5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

Guidance literature:: In dichloromethane;

Reference yield:

: 503614-44-6
lithium 1-tert-butoxy-4-(2-furyl)-1,4-dioxo-2-buten-2-olate

: 503613-35-2
5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: acetic acid / 1.5 h / 40 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.5 h

4.1: N,N-dimethyl-formamide; ammonia / 1,4-dioxane; dichloromethane / 0.5 h

5.1: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 0.7 h

6.1: potassium permanganate; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.17 h / 60 °C

7.1: triethylamine / diethyl ether / 1.5 h / 23 °C

8.1: n-butyllithium; diisopropylamine / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.33 h / -78 °C

8.2: 12 h / -78 - 23 °C

9.1: water; sulfuric acid / methanol / 96 h / Reflux

10.1: water; sulfuric acid / 2 h

With pyridine; potassium permanganate; sodium dihydrogenphosphate; n-butyllithium; oxalyl dichloride; sulfuric acid; ammonia; water; triethylamine; diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; acetic acid; tert-butyl alcohol;