Technology Process of (S)-(-)-2',2-dimethoxy-6-(p-tolylsulfinyl)biphenyl
There total 6 articles about (S)-(-)-2',2-dimethoxy-6-(p-tolylsulfinyl)biphenyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S(S))-(-)-2-iodo-1-methoxy-3-(p-tolylsulfinyl)benzene;
With
1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate;
In
1,4-dioxane;
at 20 ℃;
for 0.25h;
Inert atmosphere;
2-Methoxyphenylboronic acid;
With
cesium fluoride;
In
1,4-dioxane;
for 12h;
diastereoselective reaction;
Inert atmosphere;
Reflux;
DOI:10.1021/ol9020755
- Guidance literature:
-
(S(S))-(-)-2-iodo-1-methoxy-3-(p-tolylsulfinyl)benzene;
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane;
at 20 ℃;
for 1h;
pinacol 2-anisylboronate;
With
cesium fluoride;
In
1,3-dioxane;
at 70 ℃;
for 3h;
DOI:10.1002/adsc.201300446
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / toluene / 6 h / 20 °C / Cooling with ice
2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / Inert atmosphere; Cooling with acetone-dry ice
2.2: 1 h / -78 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
3.2: 0.17 h / -78 °C / Inert atmosphere
4.1: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 1 h / 20 °C
4.2: 3 h / 70 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; tris-(dibenzylideneacetone)dipalladium(0); n-butyllithium; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; hexane; toluene;
4.1: |Suzuki-Miyaura Coupling / 4.2: |Suzuki-Miyaura Coupling;
DOI:10.1002/adsc.201300446
