8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

Base Information

Chemical Name:8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine
CAS No.:1254980-38-5
Molecular Formula:C₂₃H₂₅F₃N₄
Molecular Weight:414.474
Hs Code.:

Synonyms:8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

Suppliers and Price of 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

There total 4 articles about 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 771-99-3
4-phenylpiperidine

: 1254982-05-2
7-((methylsulfonyloxy)methyl)-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 1254980-38-5
8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 4h; Sealed tube;

Reference yield: 25.0%

: 1152617-06-5
potassium trifluoro[(4-phenyl-1-piperidinyl)methyl]-borate^(1-)

: 1254981-30-0
7-chloro-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 1254980-38-5
8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: With caesium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; water; at 20 - 80 ℃; for 120h; Inert atmosphere;

Reference yield:

: 1254981-30-0
7-chloro-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 1254980-38-5
8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,4-dioxane / 0.22 h / 150 °C / Microwave irradiation

2: osmium(VIII) oxide; sodium periodate / tert-butyl alcohol; water; 1,4-dioxane / 2 h / 20 °C

3: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 100 °C / Sealed tube

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol; 1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00913