2-deuterio-phenyl dimethylcarbamate

Base Information

• Chemical Name: 2-deuterio-phenyl dimethylcarbamate
• CAS No.: 1360939-08-7
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 166.184
• Mol file: 1360939-08-7.mol

Synonyms:2-deuterio-phenyl dimethylcarbamate

Chemical Property of 2-deuterio-phenyl dimethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-deuterio-phenyl dimethylcarbamate

There total 2 articles about 2-deuterio-phenyl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxybromobenzene (95-56-7) → 2-deuterio-phenyl dimethylcarbamate (1360939-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether / 3.75 h / 0 °C / Sealed tube

1.2: 0 - 20 °C / Sealed tube

2.1: potassium carbonate / acetonitrile / 4 h / Reflux; Sealed tube

With tert.-butyl lithium; potassium carbonate; In diethyl ether; acetonitrile;

DOI:10.1039/c3cc47431c

Reference yield:

<2-D>-phenol (23951-01-1) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 2-deuterio-phenyl dimethylcarbamate (1360939-08-7)

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Reflux; Sealed tube;

DOI:10.1039/c3cc47431c DOI:10.1039/c5cc02533h

Reference yield:

2-deuterio-phenyl dimethylcarbamate (1360939-08-7) → 2-bromo-6-chlorophenol (2040-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-chloro-succinimide; palladium diacetate; sodium pyrosulfate; trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C / Sealed tube

2: palladium diacetate; trifluorormethanesulfonic acid; N-Bromosuccinimide / 1,2-dichloro-ethane / 6 h / 20 °C / Sealed tube

3: hydrazine hydrate / 12 h / 20 °C / Sealed tube

With N-chloro-succinimide; N-Bromosuccinimide; sodium pyrosulfate; trifluorormethanesulfonic acid; palladium diacetate; hydrazine hydrate; In 1,2-dichloro-ethane;

DOI:10.1039/c3cc47431c

upstream raw materials:

<2-D>-phenol

N,N-Dimethylcarbamoyl chloride

2-hydroxybromobenzene

Downstream raw materials:

o-chlorophenyl dimethylcarbamate

C₉H₉⁽²⁾HClNO₂

2,6-dichlorophenyl dimethylcarbamate

2,6-Dichlorophenol

Refernces

• 1、 Sun, Xiuyun,Sun, Yonghui,Zhang, Chao,Rao, Yu. "Room-temperature Pd-catalyzed C-H chlorination by weak coordination: One-pot synthesis of 2-chlorophenols with excellent regioselectivity". supporting information. p. 1262 - 1264. Retrieved 2014/02/14.