o-chlorophenyl dimethylcarbamate

Base Information

• Chemical Name: o-chlorophenyl dimethylcarbamate
• CAS No.: 7305-01-3
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.637
• Mol file: 7305-01-3.mol

Synonyms:o-chlorophenyl dimethylcarbamate

Chemical Property of o-chlorophenyl dimethylcarbamate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-chlorophenyl dimethylcarbamate

There total 9 articles about o-chlorophenyl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenyl N,N-dimethylcarbamate (6969-90-0) → o-chlorophenyl dimethylcarbamate (7305-01-3)

Guidance literature:

With N-chloro-succinimide; trifluorormethanesulfonic acid; palladium diacetate; In 1,2-dichloro-ethane; at 20 ℃; for 11h; regioselective reaction; Sealed tube;

DOI:10.1039/c3cc47431c

Reference yield:

2-monochlorophenol (95-57-8) + N,N-Dimethylcarbamoyl chloride (79-44-7) → o-chlorophenyl dimethylcarbamate (7305-01-3)

Guidance literature:

With pyridine; In benzene;

DOI:10.1021/jo01342a039

Reference yield:

2-deuterio-phenyl dimethylcarbamate (1360939-08-7) → o-chlorophenyl dimethylcarbamate (7305-01-3) + C9H9(2)HClNO2 (1534364-43-6)

Guidance literature:

With N-chloro-succinimide; sodium pyrosulfate; trifluorormethanesulfonic acid; palladium diacetate; In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h; Sealed tube;

DOI:10.1039/c3cc47431c

upstream raw materials:

2-monochlorophenol

N,N-Dimethylcarbamoyl chloride

dichloromethylenedimethyliminium chloride

phenol

Downstream raw materials:

(E)-ethyl 3-{3-chloro-2-[(N,N-dimethylcarbamoyl)oxy]phenyl}acrylate

2,6-dichlorophenyl dimethylcarbamate

2,6-Dichlorophenol

2-bromo-6-chlorophenol

Refernces

• 1、 Sun, Xiuyun,Sun, Yonghui,Zhang, Chao,Rao, Yu. "Room-temperature Pd-catalyzed C-H chlorination by weak coordination: One-pot synthesis of 2-chlorophenols with excellent regioselectivity". supporting information. p. 1262 - 1264. Retrieved 2014/02/14.
• 2、 Gong, Tian-Jun,Xiao, Bin,Liu, Zhao-Jing,Wan, Jian,Xu, Jun,Luo, Dong-Fen,Fu, Yao,Liu, Lei. "Rhodium-catalyzed selective C-H activation/olefination of phenol carbamates". supporting information; experimental part. p. 3235 - 3237. Retrieved 2011/08/22.