6-nitro-3,4-dihydroquinolin-2(1H)-one

Base Information

Chemical Name:6-nitro-3,4-dihydroquinolin-2(1H)-one
CAS No.:22246-16-8
Molecular Formula:C9H8N2O3
Molecular Weight:192.174
Hs Code.:2933499090
European Community (EC) Number:807-862-4
DSSTox Substance ID:DTXSID10408452
Wikidata:Q82213934
Mol file:22246-16-8.mol

Synonyms:6-nitro-3,4-dihydroquinolin-2(1H)-one;22246-16-8;3,4-Dihydro-6-nitro-2(1H)-quinolinone;6-nitro-3,4-dihydro-1H-quinolin-2-one;6-nitro-1,2,3,4-tetrahydroquinolin-2-one;MFCD00559317;6-Nitro-3,4-dihydro-2(1H)-quinolinone;2(1H)-Quinolinone, 3,4-dihydro-6-nitro-;3,4-DIHYDRO-6-NITRO-1H-QUINOLIN-2-ONE;Oprea1_266243;SCHEMBL516986;AMY4819;DTXSID10408452;NQMSVHWAVMTBHK-UHFFFAOYSA-N;BCP33909;CS-B1126;AKOS003388297;AB06455;AS-18212;SY031496;6-Nitro-3,4-dihydroquinolin-2-(1H)-one;FT-0657371;EN300-41704;6-Nitro-3 pound not4-dihydroquinolin-2(1H)-one;A816049;J-014607;J-518956;F2189-0210;Z424789320

Suppliers and Price of 6-nitro-3,4-dihydroquinolin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,4-Dihydro-6-nitro-2(1H)-quinolinone
50g
$ 645.00

TRC
3,4-Dihydro-6-nitro-2(1H)-quinolinone
10g
$ 220.00

SynQuest Laboratories
3,4-Dihydro-6-nitro-1H-quinolin-2-one
1 g
$ 65.00

SynQuest Laboratories
3,4-Dihydro-6-nitro-1H-quinolin-2-one
5 g
$ 135.00

SynQuest Laboratories
3,4-Dihydro-6-nitro-1H-quinolin-2-one
25 g
$ 525.00

Medical Isotopes, Inc.
3,4-Dihydro-6-nitro-2(1H)-quinolinone
25 g
$ 2000.00

Matrix Scientific
6-Nitro-3,4-dihydroquinolin-2(1H)-one
5g
$ 59.00

Matrix Scientific
6-Nitro-3,4-dihydroquinolin-2(1H)-one
1g
$ 19.00

Matrix Scientific
6-Nitro-3,4-dihydroquinolin-2(1H)-one
25g
$ 178.00

Labseeker
6-Nitro-3,4-dihydro-2(1H)-quinolinone 95
100g
$ 846.00

Total 30 raw suppliers

Chemical Property of 6-nitro-3,4-dihydroquinolin-2(1H)-one

Chemical Property:

Vapor Pressure:2.85E-07mmHg at 25°C
Melting Point:201-202 °C
Refractive Index:1.605
Boiling Point:420.3 °C at 760 mmHg
PKA:13.45±0.20(Predicted)
Flash Point:208 °C
PSA：74.92000
Density:1.366 g/cm³
LogP:2.14070
Storage Temp.:Store below -20C
Solubility.:DMSO, Methanol
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:192.05349212
Heavy Atom Count:14
Complexity:261

Purity/Quality:

97% ^*data from raw suppliers

3,4-Dihydro-6-nitro-2(1H)-quinolinone ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC2=C1C=C(C=C2)[N+](=O)[O-]
Uses 3,4-Dihydro-6-nitro-2(1H)-quinolinone is a useful intermediate for organic synthesis. It is used in the synthesis of triazolyl dihydroquinoliinones with anticonvulsant and antidepressant activity.

Technology Process of 6-nitro-3,4-dihydroquinolin-2(1H)-one

There total 6 articles about 6-nitro-3,4-dihydroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 553-03-7
3,4-dihydro-2(1H)-quinolone

: 22246-16-8
6-nitro-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With sulfuric acid; nitric acid;
DOI:10.1016/j.bmcl.2008.07.026

Reference yield: 90.0%

: 553-03-7
3,4-dihydro-2(1H)-quinolone

: 65887-62-9
8-nitro-3,4-dihydro-2(1H)-quinolinone

: 22246-16-8
6-nitro-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With sulfuric acid; nitric acid; In water; at -10 ℃; for 3h;
DOI:10.3987/com-98-8303

Reference yield:

: 62-53-3
aniline

: 22246-16-8
6-nitro-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / acetone / 2 h / 55 °C

2: aluminum (III) chloride / 2 h / 120 °C

3: nitric acid; sulfuric acid / 1 h / 0 °C

With pyridine; aluminum (III) chloride; sulfuric acid; nitric acid; In acetone;
DOI:10.1021/ja505795s