tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate
CAS No.:1313189-48-8
Molecular Formula:C₅₁H₆₀BrNO₆S₂Si
Molecular Weight:955.162
Hs Code.:

tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

Synonyms:tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

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Chemical Property of tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

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Technology Process of tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

There total 16 articles about tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1313189-34-2
3-[2-(tert-butyldiphenylsilyloxy)ethyl]-2,4-dibromo-5-methylthiophene

: 1313189-47-7
tert-butyl N-[2-[4-(5-iodothiophen-2-yl)phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

: 1313189-48-8
tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

Guidance literature:: 3-[2-(tert-butyldiphenylsilyloxy)ethyl]-2,4-dibromo-5-methylthiophene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; Inert atmosphere; Heating;

tert-butyl N-[2-[4-(5-iodothiophen-2-yl)phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate; With triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; hexane; at 40 ℃; for 18h; Inert atmosphere;
DOI:10.1002/ejoc.201100166

Reference yield:

: 29421-92-9
4-bromo-2-methylthiophene

: 1313189-48-8
tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.05 h / -78 °C / Inert atmosphere

1.3: 1 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: bromine; potassium acetate; acetic acid / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

4.2: Inert atmosphere; Heating

4.3: 18 h / 40 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; bromine; potassium acetate; acetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201100166

Reference yield:

: 554-14-3
2-Methylthiophene

: 1313189-48-8
tert-butyl N-[2-[4-[4'-bromo-3'-(2-tert-butyldiphenylsilyloxy)ethyl-5'-methyl[2,2']bithiophen-5-yl]phenoxy]ethyl]-N-[3-(4-methoxybenzyloxy)propyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; perchloric acid / N,N-dimethyl-formamide / 50 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.05 h / -78 °C / Inert atmosphere

3.3: 1 h / -78 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: bromine; potassium acetate; acetic acid / 0 - 20 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

6.2: Inert atmosphere; Heating

6.3: 18 h / 40 °C / Inert atmosphere

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; perchloric acid; bromine; potassium acetate; acetic acid; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201100166