(R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate
CAS No.:1433280-63-7
Molecular Formula:C₂₃H₂₅BrClF₃N₄O₄
Molecular Weight:593.828
Hs Code.:

Synonyms:(R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate

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Chemical Property of (R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate

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Technology Process of (R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate

There total 7 articles about (R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175278-22-5
4-amino-3-(trifluoromethoxy)benzoic acid

: 1433280-63-7
(R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: N-chloro-succinimide / acetonitrile; N,N-dimethyl acetamide / 1 h / 20 - 60 °C

3.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile; water / 1 h / 20 - 60 °C

4.1: water; lithium hydroxide / methanol / 0.5 h / 75 °C

4.2: pH Ca_. 1

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; tert.-butylnitrite; water; N-ethyl-N,N-diisopropylamine; HATU; copper(ll) bromide; lithium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1433280-63-7
(R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: hydrogen; 20% palladium hydroxide-activated charcoal / methanol

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 20 °C

With 20% palladium hydroxide-activated charcoal; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl acetamide; dimethyl sulfoxide;

Reference yield:

: 1374892-20-2
(R)-3-methyl-4-(5-nitropyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1433280-63-7
(R)-tert-butyl 4-(5-(4-bromo-3-chloro-5-(trifluoromethoxy)benzamido)pyridin-2-yl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 20 °C

With 20% palladium hydroxide-activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl acetamide;