methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

Base Information

Chemical Name:methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate
CAS No.:1374135-27-9
Molecular Formula:C₂₂H₂₂N₂O₄S
Molecular Weight:410.494
Hs Code.:

Synonyms:methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

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Chemical Property of methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

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Technology Process of methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

There total 8 articles about methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.7%

: 944317-70-8
[5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methanol

: 1374135-28-0
[2-methoxy-5-[4-(methoxycarbonyl)-2-methylphenyl]phenyl]boronic acid

: 1374135-27-9
methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 8h; Inert atmosphere;

Reference yield:

: 934236-94-9
methyl 4-(4-methoxyphenyl)-3-methylbenzoate

: 1374135-27-9
methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: silver sulfate; iodine / methanol; ethyl acetate / 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -25 - -15 °C / Inert atmosphere

2.2: 1.5 h / -20 - 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 10 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; isopropylmagnesium chloride; caesium carbonate; silver sulfate; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;

Reference yield:

: 934842-18-9
methyl 4-(3-iodo-4-methoxyphenyl)-3-methylbenzoate

: 1374135-27-9
methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -25 - -15 °C / Inert atmosphere

1.2: 1.5 h / -20 - 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 10 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; isopropylmagnesium chloride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;