methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate

Base Information

Chemical Name:methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate
CAS No.:1374135-59-7
Molecular Formula:C₂₃H₂₄N₂O₆S₂
Molecular Weight:488.585
Hs Code.:

Synonyms:methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate

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Chemical Property of methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate

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Technology Process of methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate

There total 9 articles about methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374135-27-9
methyl 3'-[4-(hydroxymethyl)-2-(methylsulfanyl)pyrimidin-5-yl]-4'-methoxy-2-methylbiphenyl-4-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1374135-59-7
methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

Reference yield:

: 7697-28-1
4-bromo-3-methylbenzoic acid

: 1374135-59-7
methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 7 h / 10 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere

3.1: silver sulfate; iodine / methanol; ethyl acetate / 3 h / 20 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -25 - -15 °C / Inert atmosphere

4.2: 1.5 h / -20 - 0 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 10 h / 100 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; iodine; isopropylmagnesium chloride; caesium carbonate; silver sulfate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1374135-59-7
methyl 4'-methoxy-2-methyl-3'-[2-(methylsulfanyl)-4-{[(methylsulfonyl)oxy]methyl}pyrimidin-5-yl]biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere

2.1: silver sulfate; iodine / methanol; ethyl acetate / 3 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -25 - -15 °C / Inert atmosphere

3.2: 1.5 h / -20 - 0 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 10 h / 100 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; isopropylmagnesium chloride; caesium carbonate; silver sulfate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;