(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester

Base Information

Chemical Name:(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester
CAS No.:174768-04-8
Molecular Formula:C₂₁H₂₂NO₄P
Molecular Weight:383.384
Hs Code.:

Synonyms:(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester

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Chemical Property of (1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester

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Technology Process of (1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester

There total 5 articles about (1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 174768-03-7
(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid

: 174768-04-8
(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester

Guidance literature:: With tetramethylsilane; In 1,4-dioxane; methanol;
DOI:10.1016/0960-894X(96)00211-9

Reference yield:

: 3857-83-8
2-naphthyl triflate

: 174768-04-8
(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / Pd(OAc)2, PPh₃, Et₃N / dimethylformamide

2: 91 percent / H₃PO₂, HCl / dioxane

3: 1.) TFA, 2.) NaOH / 1.) anisole, 85-90 deg C, 3 h

4: 93 percent / TMS / dioxane; methanol

With hydrogenchloride; palladium diacetate; sodium hydroxide; tetramethylsilane; hypophosphorous acid; triethylamine; triphenylphosphine; trifluoroacetic acid; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00211-9

Reference yield:

: 135-19-3
β-naphthol

: 174768-04-8
(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / piridine / Ambient temperature

2: 61 percent / Pd(OAc)2, PPh₃, Et₃N / dimethylformamide

3: 91 percent / H₃PO₂, HCl / dioxane

4: 1.) TFA, 2.) NaOH / 1.) anisole, 85-90 deg C, 3 h

5: 93 percent / TMS / dioxane; methanol

With pyridine; hydrogenchloride; palladium diacetate; sodium hydroxide; tetramethylsilane; hypophosphorous acid; triethylamine; triphenylphosphine; trifluoroacetic acid; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00211-9