15231-41-1

Basic information

• Product Name: tert-butyl 3-aminopropanoate
• Synonyms: tert-butyl 3-aminopropanoate;3-Aminopropionic acid tert-butyl ester;b-Alanine, 1,1-diMethylethyl ester;tert-Butyl b-alaninate;b-Alanine tert-butyl ester
• CAS NO: 15231-41-1
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Mol File: 15231-41-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 192 ºC
• Flash Point: 64 ºC
• Appearance: /
• Density: 0.959
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.67±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 3-aminopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-aminopropanoate(15231-41-1)
• EPA Substance Registry System: tert-butyl 3-aminopropanoate(15231-41-1)

Safety Data

• Hazardous Substances Data: 15231-41-1(Hazardous Substances Data)

Usage

Uses

tert-Butyl 3-Aminopropanoate is an intermediate useful in the synthesis of rac-3-Oxo Atorvastatin Sodium Salt (O847150), which is a byproduct impurity of Atorvastatin Calcium (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.

Upstream product

• 115-11-7 isobutene 
• 107-95-9 3-amino propanoic acid 
• 1663-39-4 tert-Butyl acrylate 
• 102124-10-7 tert-butyl 3-(benzylamino)propanoate 
• 1116-98-9 cyanoacetic acid tert-butyl ester 
• 58620-93-2 tert-butyl 3-aminopropanoate hydrochloride 
• 18605-26-0 3-(((benzyloxy)carbonyl)amino)propionic tert-butyl ester 

Downstream Products

• 120397-45-7 (E)-3-(2-tert-Butoxycarbonyl-ethylcarbamoyl)-4-phenyl-but-3-enoic acid ethyl ester 
• 871250-79-2 (R,S)-tert-butyl 3-(4-{1-[6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-propoxy}-benzoylamino)-propionate 
• 1242063-16-6 tert-butyl N-(4-{1-[1-(4-chlorophenyl)-2-hydroxyethyl]butyl}benzoyl)-β-alaninate 

Relevant articles and documents

Oxidation of Nω-hydroxyarginine analogues by NO-synthase: The simple, non amino acid N-butyl N′-hydroxyguanidine is almost as efficient an NO precursor as Nω-hydroxyarginine

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Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

A series of (E)-3-(4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxyphenyl)-2-cyanoacrylamide derivatives were designed and synthesized as new estrogen-related receptor α (ERRα) degraders based on the proteolysis targeting chimera (PROTAC) concept. One of the representative compounds 6c is capable of specifically degrading ERRα protein by >80% at a relatively low concentration of 30 nM, becoming one of the most potent and selective ERRα degraders to date. Compound 6c could be utilized as a new powerful research tool for further biological investigation of ERRα.

Synthesis and structure of a bis-glycosylated hexa-β-peptide

The bis-glycosylated hexapeptide β-Ala-β-Ala-(β-D-Glc)-L- Asp-β-Ala-β-Ala-(β-D-Gal)-L-Asp (14) is prepared by fragment condensation of Fmoc-β-Ala-β-Ala-(β-D-GlcAc4)-L-Asp-OH (11) and H2N-β-Ala-β-Ala-(β-D-GalAc4)-L-Asp-OtBu (12) under optimized conditions