2-Methoxyphenyl chloroformate

Base Information

• Chemical Name: 2-Methoxyphenyl chloroformate
• CAS No.: 2293-75-6
• Molecular Formula: C8H7 Cl O3
• Molecular Weight: 186.595
• European Community (EC) Number: 626-544-4
• DSSTox Substance ID: DTXSID00391804
• Wikidata: Q82189523
• Mol file: 2293-75-6.mol

Synonyms:2-Methoxyphenyl chloroformate;2293-75-6;(2-methoxyphenyl) carbonochloridate;2-methoxyphenyl carbonochloridate;MFCD02093715;2-METHOXYPHENYLCHLOROFORMATE;2-methoxyphenol chloroformate;SCHEMBL297205;2-methoxyphenylcarbonochloridate;2-(methoxy)phenyl chloroformate;DTXSID00391804;VDLQSPNQAVRJND-UHFFFAOYSA-N;2-Methoxyphenyl chloroformate, 98%;AKOS015912897;SY297050;EN300-267049;J-014909

Chemical Property of 2-Methoxyphenyl chloroformate

Chemical Property:

• Vapor Pressure: 0.0322mmHg at 25°C
• Refractive Index: n20/D 1.519(lit.)
• Boiling Point: 244 °C(lit.)
• Flash Point: 110 °C
• PSA: 35.53000
• Density: 1.253 g/mL at 25 °C(lit.)
• LogP: 2.43280
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 186.0083718
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

98%Min ^*data from raw suppliers

2-methoxyphenylchloroformate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,C
• Statements: 25-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OC(=O)Cl

Technology Process of 2-Methoxyphenyl chloroformate

There total 5 articles about 2-Methoxyphenyl chloroformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bis(trichloromethyl) carbonate (32315-10-9) + 2-methoxy-phenol (90-05-1) → 2-methoxyphenyl chlorocarbonate (2293-75-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2016.09.070

Reference yield: 50.0%

phosgene (75-44-5) + 2-methoxy-phenol (90-05-1) → 2-methoxyphenyl chlorocarbonate (2293-75-6)

Guidance literature:

N,N-dimethyl-formamide; In N,N-dimethyl-aniline; chlorobenzene; toluene;

Reference yield:

phosgene (75-44-5) → 2-methoxyphenyl chlorocarbonate (2293-75-6)

Guidance literature:

With antipyrine; Einw_. von Guajacol auf das Additionsprodukt;

upstream raw materials:

phosgene

sodium 2-methoxyphenolate

2-methoxy-phenol

bis(trichloromethyl) carbonate

Downstream raw materials:

hexakis-O-(2-methoxy-phenoxycarbonyl)-D-mannitol

carbonic acid-(5-acetyl-[8]quinolyl ester)-(2-methoxy-phenyl ester)

phosgene

bis(2-methoxy-phenyl)carbonate

Refernces

• 1、 -. "NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES". Page/Page column 45. . Retrieved 2009/12/05.