1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Base Information

• Chemical Name: 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole
• CAS No.: 1613694-69-1
• Molecular Formula: C₂₈H₃₄N₄O₂
• Molecular Weight: 458.604

Synonyms:1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Chemical Property of 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

There total 6 articles about 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde (1613695-19-4) + cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8) → 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole (1613694-69-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/ja412434f

Reference yield:

4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) → 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole (1613694-69-1)

Guidance literature:

Multi-step reaction with 5 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 80 °C

3: sodium dithionite / methanol / 2 h / 80 °C

4: trifluoroacetic acid / water; dichloromethane / 0.83 h / 150 °C / Microwave irradiation

5: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C

With sodium dithionite; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; 1: |Suzuki Coupling;

DOI:10.1021/ja412434f

Reference yield:

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole (832114-00-8) → 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole (1613694-69-1)

Guidance literature:

Multi-step reaction with 5 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 80 °C

3: sodium dithionite / methanol / 2 h / 80 °C

4: trifluoroacetic acid / water; dichloromethane / 0.83 h / 150 °C / Microwave irradiation

5: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C

With sodium dithionite; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; 1: |Suzuki Coupling;

DOI:10.1021/ja412434f

upstream raw materials:

4-Bromo-1-fluoro-2-nitrobenzene

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

4-(4-fluoro-3-nitrophenyl)-3,5-dimethyl-1,2-oxazole

[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazol-1-yl]acetaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1613694-69-1 1-{2-[(cis-2,6-dimethylmorpholin-4-yl)]ethyl}-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)-1H-benzimidazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send