2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

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Chemical Name:2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide
CAS No.:1207760-89-1
Molecular Formula:C₂₂H₂₃ClN₆O₃S₂
Molecular Weight:519.048
Hs Code.:

Synonyms:2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

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Chemical Property of 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

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Technology Process of 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

There total 6 articles about 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1082528-89-9
1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-thiol

: 1207760-90-4
2-bromo-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

: 1207760-89-1
2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 61072-66-0
2-bromo-4-(2-methoxyethoxy)butanoic acid

: 1207760-89-1
2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.090

Reference yield:

: 1006597-09-6
1-(2-chloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

: 1207760-89-1
2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thio}-4-(2-methoxyethoxy)-N-(4-methyl-1,3-thiazol-2-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: Lawessons reagent / tetrahydrofuran / 4 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With Lawessons reagent; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.090