Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester
• CAS No.: 764723-42-4
• Molecular Formula: C₂₆H₃₂O₇S
• Molecular Weight: 488.602
• Mol file: 764723-42-4.mol

Synonyms:Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester

Chemical Property of Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester

There total 2 articles about Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

C33H38O10S2 (764723-41-3) → Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester (764723-42-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium cyanoborohydride; at 120 ℃;

DOI:10.1016/j.tetasy.2004.06.017

Reference yield:

1-((5aR,6S,9R,9aS)-3,6-Dihydroxy-6-hydroxymethyl-9-isopropyl-1-methoxy-5a,6,7,8,9,9a-hexahydro-dibenzofuran-4-yl)-ethanone (764723-50-4) → Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester (764723-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

2: 58 percent / NaBH₃CN; HMPA / 120 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium cyanoborohydride; triethylamine; In dichloromethane;

DOI:10.1016/j.tetasy.2004.06.017

Reference yield: 88.0%

benzaldehyde (100-52-7) + Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester (764723-42-4) → (5aR*,6R*,9R*,9aS*)-4-cinnnamoyl-3,6-dihydroxy-1-methoxy-6-methyl-9-(1-methylethyl)-5a,6,7,8,9,9a-hexahydrodibenzofuran

Guidance literature:

benzaldehyde; Toluene-4-sulfonic acid (5aR,6R,9R,9aS)-4-acetyl-6-hydroxy-9-isopropyl-1-methoxy-6-methyl-5a,6,7,8,9,9a-hexahydro-dibenzofuran-3-yl ester; With potassium tert-butylate; In tert-butyl alcohol;

With potassium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.tetasy.2004.06.017

upstream raw materials:

C₃₃H₃₈O₁₀S₂

1-((5aR,6S,9R,9aS)-3,6-Dihydroxy-6-hydroxymethyl-9-isopropyl-1-methoxy-5a,6,7,8,9,9a-hexahydro-dibenzofuran-4-yl)-ethanone